charged multivesicular body protein 1A; chromatin-modifying protein 1a; CHMP1a; vacuolar protein sorting-associated protein 46-1; Vps46-1; hVps46-1 (CHMP1A, CHMP1, KIAA0047, PCOLN3, PRSM1)

Function: 1) component of ESCRT3 in the multivesicular body pathway 2) interaction with VPS4A & VPS4B mediates ATP-dependent disassembly of the ESCRT3 3) self-associates 4) interacts with CHMP1B, VPS4A, VPS4B, PHF1, IST1 Structure: belongs to the SNF7 family Compartment: - cytoplasm, endosome - endosomal membrane, peripheral membrane - nuclear form remains associated with the chromosome scaffold during mitosis - on overexpression,localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin Alternative splicing: named isoforms=2 Expression: - expressed in placenta, cultured skin, fibroblasts, osteoblast cell line MG63 - induced by muristerone Notes: - originally thought to be a metalloprotease PRSM1, based on a wrong translation of the ORF - procollagen-3 & CHMP1 are encoded by different ORFs in the PCOLN3 gene

Properties

SIZE: entity length = 196 aa MW = 22 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl coiled coil {5-47} coiled coil {102-124} MIT-interacting {185-195}

Database Correlations

OMIM 164010 UniProt Q9HD42 Pfam PF03357

References

UniProt :accession Q9HD42