chlorpheniramine/codeine/pseudoephedrine (Dihistine DH, Novahistine DH)

DEA-controlled substance: class 4. Indications: 1) temporary relief of cough associated with minor throat or bronchial irritation 2) nasal congestion due to common cold, allergic rhinitis, or sinusitis Cantraindications: 1) severe hypertension 2) coronary artery disease 3) concurrent MAO inhibitor therapy Dosage: 1) adults & chldren > 12 years: a) 10 mL every 4-6 hours PRN b) max: 40 mL/24 hours 2) children 6-12 years: a) 2.5-5 mL every 4-6 hours PRN b) max: 4 doses/day 3) children 2-6 years: a) 1.25-2.5 mL every 4-6 hours PRN b) max: 4 doses/day Liquid: chlorpheniramine maleate 2 mg, pseudoephedrine HCl 30 mg codeine phosphate 10 mg (120 mL, 240 mL) Adverse effects: - not common (1-10%) - sedation, dizziness, drowsiness, increased intracranial pressure, constipation, hypotension, biliary spasm, urinary tract spasm, dependence

References

Kaiser Permanente Northern California Regional Drug Formulary, 1998

Components

chlorpheniramine (Chlor-Trimeton) codeine pseudoephedrine (Sudafed, Afrin, Drixoral, SudoGest)