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chloride channel protein ClC-Ka; chloride channel Ka; ClC-K1 (CLCNKA)
Function:
- voltage-gated chloride channel
- chloride channels have several functions including
a) regulation of cell volume
b) membrane potential stabilization
c) signal transduction
d) transepithelial transport
- may be important in urinary concentrating mechanisms
- interacts with barttin (BSND)
- forms heteromers with BSND in the thin ascending limb of Henle (putative)
Structure:
- belongs to the chloride channel (TC 2.A.49) family
- contains 2 CBS domains
Compartment: membrane
Expression:
- expressed predominantly in the kidney
- all nephron segments expressing barttin (BSND) also express CLCNK proreins
Related
CLCKA gene
General
Cl- channel
phosphoprotein
transmembrane 10 protein
Properties
SIZE: entity length = 687 aa
MW = 75 kD
COMPARTMENT: plasma membrane
MOTIF: transmembrane domain {52-72}
transmembrane domain {161-181}
transmembrane domain {202-222}
transmembrane domain {236-256}
transmembrane domain {282-302}
transmembrane domain {329-349}
transmembrane domain {396-416}
transmembrane domain {417-437}
transmembrane domain {452-472}
transmembrane domain {486-506}
CBS 1 {551-609}
CBS 2 {626-684}
MOTIF: Ser phosphorylation site {S660}
ION-PERMEABILITY: Cl-
Database Correlations
OMIM 602024
MORBIDMAP 602024
UniProt P51800
PFAM correlations
Entrez Gene 1187
Kegg hsa:1187
References
UniProt :accession P51800