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cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia, CHIC2, BTL)
Structure:
- belongs to the CHIC family
- palmitoylated
Compartment:
- cell membrane, cytoplasmic vesicle
- present at a Golgi-like vesicular compartment & at scattered vesicles
Pathology:
- chromosomal translocation t(4;12)(q12;p13) involving CHIC2 with ETV6 is found in a form of acute myeloid leukemia (AML)
General
other protein
Properties
SIZE: MW = 19 kD
entity length = 165 aa
COMPARTMENT: cytoplasm
golgi
MOTIF: coiled coil {1-26}
MOTIF: glutamate-rich region {9-15}
MOTIF: glutamate residue (SEVERAL)
cysteine-rich region {88-106}
Breakpoint {111-112}
Database Correlations
OMIM 604332
UniProt Q9UKJ5
References
- UniProt :accession Q9UKJ5
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/CHIC2ID373.html