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chemokine; chemoattractant
class of cytokines
* see Figure: CC ligand & receptor binding
* see Figure: CXC ligand & receptor binding
Function:
- attract & activate leukocytes
- other functions:
a) hematopoietic/lymphopoietic system
1] regulation of stem cell maturation
2] formation of secondary lymphoid tissues
3] angiogenesis
b) control of organogenesis
c) participate in development of cerebellum & hippocampus
d) maturation and migration of stem cells
e) role in neuroinflammatory disorders
- role in guiding inflammatory cells to sites of inflammation in the brain
Related
chemokine receptor (chemoattractant receptor)
Specific
C chemokine
CC chemokine; beta chemokine
chemokine like factor super family member
CX3C or CXXXC chemokine
CXC chemokine; alpha chemokine
General
cytokine
Figures/Diagrams
Figures/diagrams/slides/tables related to chemokine
Properties
COMPARTMENT: extracellular compartment
References
- Baggiolini M et al.
Interleukin-8 and related chemotactic cytokines--CXC and
CC chemokines.
Adv Immunol 55:97-179 1994
PMID: 8304236
- Tran PB & Miller RJ.
Chemokine receptors: signposts to brain development and disease.
Nature Reviews Neuroscience 4:444-455, 2003
PMID: 12778117
- Abbadie C, Bhangoo S, De Koninck Y et al
Chemokines and pain mechanisms.
Brain Res Rev. 2009 Apr;60(1):125-34
PMID: 19146875