Search
ubiquitin carboxyl-terminal hydrolase BAP1; BRCA1-associated protein 1; cerebral protein 6 (BAP1, KIAA0272, hucep-6)
Function:
1) deubiquitinating enzyme
2) thiol-dependent hydrolysis of ester,thiolester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
3) may be involved in BRCA1 signal transduction pathway.
4) interacts with the RING finger domain of BRCA1
Compartment: nucleus.
Expression: expressed testis, placenta, ovary, breast
Pathology:
1) defects in BAP1 are found in non-small cell lung cancer cell lines
2) tumor-associated antigen found in some childhood medulloblastomas
General
ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme
Properties
SIZE: MW = 80 kD
entity length = 729 aa
MOTIF: cysteine residue {C91}
histidine residue {H169}
aspartate residue {D184}
Thr phosphorylation site {T487}
Ser phosphorylation site {S489}
binding site
SITE: 596-721
FOR-BINDING-OF: BRCA1 protein
MOTIF: coiled coil {630-661}
Database Correlations
OMIM 603089
UniProt Q92560
Pfam PF01088
ENZYME 3.4.19.12
References
UniProt :accession Q92560