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cerebellin-1 (CBLN1)
Function:
1) neuromodulatory functions
2) stimulates norepinephrine release via the adenylate cyclase PKA-dependent signaling pathway
3) indirectly enhances adrenocortical secretion in vivo via a paracrine mechanism involving medullary catecholamine release
4) forms complexes with CBLN3
5) contains 1 C1q domain
Compartment:
- secreted, membrane
- in the Purkinje cells postsynaptic structures
Expression:
- low at birth, increases days 5-15, reaches peak values day 21-56
General
cerebellin
membrane protein
Properties
SIZE: MW = 21 kD
entity length = 193 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
N-glycosylation site {N23}
N-glycosylation site {N41}
C1Q {57-193}
MOTIF: N-glycosylation site {N79}
Database Correlations
OMIM 600432
UniProt P23435
Pfam PF00386
Entrez Gene 869
Kegg hsa:869
References
UniProt :accession P23435