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ceramide
N-acyl sphingosine; Putative mediator of TNF-alpha, vitamin D3, IFN-gamma, IL-1 & NGF signals. Ceramide in turn regulates PLC-zeta, an unidentified serine/threonine protein phosphatase & an unidentified membrane-associated proline-directed protein kinase. Ceramide* may also activate phospholipase A2 & cyclo- oxygenase-2 [2,3] & has been implicated in apoptosis [2]. The role of ceramide in transducing the signal of NGF would suggest a potentiating rather than mediating role in apoptosis, because NGF does not induce apoptosis. Ceramide inhibits phospholipase-D [2].
* ceramide-1-phosphate activates phospholipase A2 [4]
Interactions
molecular events
Related
cyclooxygenase (prostaglandin endoperoxide synthase, COX)
phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
phospholipase-D (PLD)
Specific
globoside (cytolipin)
General
pro apoptotic molecule
sphingolipid
Properties
COMPARTMENT: plasma membrane
Database Correlations
PUBCHEM correlations
References
- Liscovitch M.
Crosstalk among multiple signal-activated phospholipases.
Trends Biochem Sci. 1992 Oct;17(10):393-9. Review.
PMID: 1455508
- Hannun YA, Obeid LM.
Ceramide: an intracellular signal for apoptosis.
Trends Biochem Sci. 1995 Feb;20(2):73-7. Review.
PMID: 7701566
- Wu D, Meydani SN.
Mechanism of age-associated up-regulation in macrophage PGE2
synthesis.
Brain Behav Immun. 2004 Nov;18(6):487-94. Review.
PMID: 15331118
- Pettus BJ, Kitatani K, Chalfant CE, Taha TA, Kawamori T,
Bielawski J, Obeid L, Hannun YA.
The Coordination of Prostaglandin E2 production by sphingosine-
1-phosphate and ceramide-1- phosphate.
Mol Pharmacol. 2005 May 17; [Epub ahead of print]
PMID: 15900018