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cephapirin (Cefadyl)
Tradename: Cefadyl. 1st generation cephalosporin. 0.5-2 g IV/IM every 4-6 hours.
Pharmacokinetics:
1) esterfied to metabolite with 54% activity of parent compound
2) metabolite may accumulate with parent compound in renal failure
Adverse effects:
1) eosinophilia
2) allergic rashes
3) fever
4) malaise
5) headache
6) joint & muscle pain
7) neutropenia
8) transient increase in ALT, AST & alkaline phosphatase
Test interactions:
-> positive direct Coomb's test
Laboratory:
1) specimen:
a) serum
b) keep specimen on ice-water
c) centrifuge at 4 degrees C
d) remove cells as soon as possible
e) freeze at -70 degrees C until assayed
2) methods: HPLC, MB
Interactions
drug interactions
drug adverse effects of cephalosporins
General
cephalosporin, 1st generation
Properties
MISC-INFO: elimination route KIDNEY
LIVER
1/2life 1.2 HOURS
protein-binding 58%
elimination by hemodialysis +
peritoneal dialysis -
pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995