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centrosomal protein of 152 kD (Cep152, KIAA0912)
Function:
- regulator of genomic integrity & cellular response to DNA damage acting through ATR-mediated checkpoint signaling necessary for centrosome duplication
- functions as a molecular scaffold facilitating interaction of PLK4 & CENPJ, two protein involved in centriole formation
- interacts (via N-terminus) with PLK4
- interacts (via C-terminus) with CENPJ (via-N-terminus)
- interacts with CINP
Compartment:
- cytoplasm, cytoskeleton, centrosome
Alternative splicing: named isoforms=3
Pathology:
- defects in CEP152 are the cause
a) primary microcephaly type 4
b) Seckel syndrome type 5
General
centrosomal protein
phosphoprotein
Properties
SIZE: entity length = 1654 aa
MW = 189 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {234-490}
coiled coil {615-664}
coiled coil {700-772}
coiled coil {902-993}
coiled coil {1146-1185}
Tyr phosphorylation site {Y1258}
Ser phosphorylation site {S1405}
Database Correlations
OMIM correlations
UniProt O94986
Entrez Gene 22995
Kegg hsa:22995
References
UniProt :accession O43303