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centromere antibody in serum

Etiology: - present in 70 to >90% of patients with CREST syndrome [2] - sensitivity for CREST syndrome 10-30% [2] - overall prevalence in systemic sclerosis ~30% [2] - present in 1% of patients with diffuse scleroderma Principle: - originally detected by immunofluorescence microscopy with the antigen localized to the region of condensing metaphase chromosomes - routinely detected via immunoblots - centromere antigens consist of three proteins, of 16, 80 & 120 kD MW. Clinical significance: - no correlation between antibody titers & disease activity - CREST syndrome patients with anti-centromere Ab are more likely to develop pulmonary hypertension [2] Specimen: 1) serum 2) store at -20 degrees C Method: test is performed using cell lines such as Hep2.

Related

anti-centromere antibody centromere CREST syndrome

Specific

centromere protein A antibody in serum centromere protein B antibody in serum centromere protein F antibody in serum

General

centromere antibody in body fluid

References

  1. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1019
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, 17. American College of Physicians, Philadelphia 1998, 2015
  3. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995