centriolin; 110 kD centrosomal protein; centrosomal protein 1 (CNTRL, CEP110, CEP1, KIAA0419)

Function: - role in cell cycle progression & cytokinesis - during the late steps of cytokinesis, anchors exocyst & SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission - interacts with HOOK2 (putative) - interacts with EXOC6 & SNAPAP - associates with the exocyst complex Structure: contains 21 LRR repeats (leucine-rich repeats) Compartment: - centrosome - during cytokinesis, localizes to a ring-like structure at the central midbody Alternative splicing: named isoforms=5 Expression: highly expressed in testis & trachea Pathology: - chromosomal translocation t(8;9)(p12;q33) involving CEP110 with FGFR1 may be a cause of stem cell myeloproliferative disorder - the fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity & may be responsible for the transforming activity

Properties

SIZE: entity length = 2325 aa MW = 269 kD MOTIF: leucine-rich repeat SITE: 97-120 MOTIF: leucine residue (SEVERAL) Tyr phosphorylation site {Y117} leucine-rich repeat SITE: 124-146 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 147-168 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 169-194 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 196-216 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 217-241 MOTIF: leucine residue (SEVERAL) coiled coil {267-343} MOTIF: Thr phosphorylation site {T286} leucine-rich repeat SITE: 530-554 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 578-602 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 650-675 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 705-729 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 813-838 MOTIF: leucine residue (SEVERAL) lysine-rich region {956-959} MOTIF: lysine residue (SEVERAL) leucine-rich repeat SITE: 986-1011 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1116-1140 MOTIF: leucine residue (SEVERAL) proline-rich region SITE: 1147-1150 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 1236-1307 MOTIF: proline residue (SEVERAL) coiled coil {1317-1393} leucine-rich repeat SITE: 1495-1521 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1646-1670 MOTIF: leucine residue (SEVERAL) Thr phosphorylation site {T1668} Thr phosphorylation site {T1671} leucine-rich repeat SITE: 1698-1722 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1821-1848 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1873-1899 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1926-1952 MOTIF: leucine residue (SEVERAL) centrosome localization {1948-2118} HOOK2 interaction {1982-2325} MOTIF: leucine-rich repeat SITE: 2073-2098 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 2123-2148 MOTIF: leucine residue (SEVERAL) peptide motif {2139-2140}

Database Correlations

OMIM 605496 SWISS-PROT correlations Pfam PF00560 Kegg hsa:1106

References

UniProt :accession Q7Z7A1