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centenarian
Individials >= 100 years of age
Epidemiology:
- 1 per 5000 in developed countries [1]
- female centenarians outnumber males 9 to 1
- men are more likely to be functionally independent than women
- male centenarians less likely to have chronic diseases than females
- male centenarians more likely to take fewer medications than females [1]
Pathology:
- processes that improve lifespan also improve healthspan
- diseases occur later in life compressing time associated with morbidity
Genetics: (biochemistry)
- proteins increased in centenarians
- MXRA5
Clinical manifestations:
- centenarians maintain cognitive function in most domains for up to 4 years [2] with slight risk of memory loss
- BMI < 27 among 8 WW II veteran centenarians [3]
- 6 of the 8 were demented (6 of 6 men, 0 of 2 women) [3]
Management:
- a healthy lifestyle increases the likelihood of becoming a centenarian [4]
Related
longevity
supercentenarian
References
- Geriatric Review Syllabus, 10th edition (GRS10)
Harper GM, Lyons WL, Potter JF (eds)
American Geriatrics Society, 2019
- George J
High Cognitive Performance at Age 100 -
Some centenarians show resilience to cognitive decline, despite brain pathology.
MedPage Today January 15, 2021
https://www.medpagetoday.com/neurology/dementia/90720
- Beker N, Ganz A, Hulsman M et al
Association of Cognitive Function Trajectories in Centenarians With
Postmortem Neuropathology, Physical Health, and Other Risk Factors
for Cognitive Decline.
JAMA Netw Open. 2021;4(1):e2031654. Jan 15
PMID: 33449094
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2775218
- Kheirbek RE et al
Life at the Extreme: Characteristics of Veteran Centenarians in Long-term Care.
Annals of Long-Term Care. Oct. 2018
https://www.hmpgloballearningnetwork.com/site/altc/articles/life-extreme-characteristics-veteran-centenarians-long-term-care
- Li Y, Wang L, Jigeer G et al
Healthy Lifestyle and the Likelihood of Becoming a Centenarian.
JAMA Netw Open. 2024;7(6):e2417931. June 20
PMID: 38900423 Free article.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820220