centromere protein H; CENP-H; interphase centromere complex protein 35; centromere autoantigen H (CENPH, ICEN35)

Function: - component of the CENPA-NAC complex - kinetochore function - chromosome segregation during mitosis - required for efficient alignment of the chromosomes on a metaphase plate - self-associates - interacts directly with CENPK - interacts with KIF2C & NDC80 - interacts with TRIM36 (putative) Structure: belongs to the centromere protein H family Compartment: - nucleus - chromosome, centromere, kinetochore - associates with active centromere-kinetochore complexes throughout the cell cycle - colocalizes with inner kinetochore plate proteins CENPA & CENPC1 during interphase & metaphase

Properties

SIZE: entity length = 247 aa MW = 28 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl coiled coil {47-192}

Database Correlations

OMIM 605607 UniProt Q9H3R5 Pfam PF05837 Entrez Gene 64946 Kegg hsa:64946

References

UniProt :accession Q9H3R5