centromere protein C 1; CENP-C; centromere autoantigen C; interphase centromere complex protein 7 (CENPC1 CENPC ICEN7)

Function: - component of the CENPA-NAC (nucleosome-associated) complex - binds to DAXX Compartment: - nucleus, centromere, kinetochore - localizes exclusively in the kinetochore domain of centromeres Pathology: - antibodies against CENPC are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins

General

DNA-binding protein phosphoprotein

Properties

SIZE: entity length = 943 aa MW = 107 kD COMPARTMENT: cell nucleus MOTIF: Thr phosphorylation site {T167} Ser phosphorylation site {S170} Ser phosphorylation site {S177} Ser phosphorylation site {S225} peptide motif {259-273} MOTIF: Ser phosphorylation site {S261} Ser phosphorylation site {S316} Ser phosphorylation site {S333} peptide motif {484-499} Ser phosphorylation site {S520} Ser phosphorylation site {S524} Ser phosphorylation site {S538} peptide motif {558-574} Ser phosphorylation site {S763} Ser phosphorylation site {S773} peptide motif {780-798}

Database Correlations

OMIM 117141 UniProt Q03188 Pfam PF07883 Kegg hsa:1060

References

UniProt :accession Q03188