CENPA-CAD (nucleosome distal) complex

Function: 1) interacts with the CENPA-NAC complex 2) recruited to centromeres 3) assembly of kinetochore proteins 4) mitotic progression & chromosome segregation 5) incorporation of newly synthesized CENPA into centromeres Structure: - consists of: - CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR, CENPS

Properties

SUBUNITS: follicle-stimulating hormone primary response protein MOTIF: Ser phosphorylation site {S22} centromere protein K COMPARTMENT: cell nucleus MOTIF: coiled coil {22-42} coiled coil {98-151} phosphorylation site centromere protein L COMPARTMENT: cell nucleus centromere protein O COMPARTMENT: cell nucleus MOTIF: coiled coil {18-42} coiled coil {83-109} centromere protein P COMPARTMENT: cell nucleus MOTIF: coiled coil {1-71} centromere protein Q COMPARTMENT: cell nucleus MOTIF: coiled coil {170-206} nuclear receptor-interacting factor 3 COMPARTMENT: cytoplasm cell nucleus MOTIF: LXXLL {9-13} Ser phosphorylation site {S17} DD1 {20-50} MOTIF: Ser phosphorylation site {S28} nuclear translocation signal {63-66} coiled coil {83-113} LXXIL {172-176} centromere protein S COMPARTMENT: cell nucleus

References

UniProt :accession Q99743

Components

centromere protein K (CENP-K, interphase centromere complex protein 37, protein AF-5alpha, p33, CENPK, ICEN37, FKSG14) centromere protein L (CENP-L, interphase centromere complex protein 33, CENPL, C1orf155, ICEN33) centromere protein O (CENP-O, interphase centromere complex protein 36, CENPO, ICEN36) centromere protein P (CENP-P, CENPP) centromere protein Q (CENP-Q, CENPQ, C6orf139) centromere protein S (CENP-S, apoptosis-inducing TAF9-like domain-containing protein 1, APITD1, CENPS) follicle-stimulating hormone primary response protein: FSH primary response protein 1; leucine-rich primary response protein 1 (FSHPRH1, LRPR1, CENPI) nuclear receptor-interacting factor 3; centromere protein R; CENP-R; beta-3-endonexin; integrin beta-3-binding protein (ITGB3BP, CENPR, NRIF3)