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cellular nucleic acid-binding protein; CNBP; zinc finger protein 9 (CNBP, RNF163, ZNF9)
Function:
- single stranded DNA-binding protein, with specificity for the sterol regulatory element (SRE)
- role in sterol-mediated repression
Structure: contains 7 CCHC-type Zn+2 fingers
Compartment:
- cytoplasm (putative)
- endoplasmic reticulum (putative)
Alternative splicing: named isoforms=3
Expression: present in all tissues examined
Pathology:
- defects in CNBP are the cause of myotonic dystrophy 2
Related
CNBP gene mutation; ZNF9 gene mutation
General
DNA-binding protein
transcriptional silencer (transcriptional repressor)
zinc finger protein
Properties
SIZE: entity length = 177 aa
MW = 19 kD
COMPARTMENT: cytoplasm
MOTIF: Zn finger C2HC-type
SITE: 4-21
EFFECTOR-BOUND: Zn+2
Zn finger C2HC-type
SITE: 52-69
EFFECTOR-BOUND: Zn+2
Zn finger C2HC-type
SITE: 72-89
EFFECTOR-BOUND: Zn+2
Zn finger C2HC-type
SITE: 96-113
EFFECTOR-BOUND: Zn+2
Zn finger C2HC-type
SITE: 117-134
EFFECTOR-BOUND: Zn+2
Zn finger C2HC-type
SITE: 135-152
EFFECTOR-BOUND: Zn+2
Zn finger C2HC-type
SITE: 156-173
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM correlations
UniProt P62633
Pfam PF00098
Entrez Gene 7555
References
- UniProt :accession P62633
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CNBP