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cellular immune dysfunction
Etiology:
1) diseases (group 1 pathogens)
a) acute & chronic lymphocytic leukemia
b) lymphoma
1] Hodgkin's disease
2] non-Hodgkin's lymphoma
d) thymus hypoplasia or aplasia
e) sarcoidosis
f) lepromatous leprosy
2) acquired immunodeficiency syndrome (AIDS)
3) inherited disorders
a) purine nucleoside phosphorylase deficiency
b) primary T-cell immunodeficiency
4) organ transplantation
5) pharmaceutical agents: (immunosuppressants)
a) cyclosporine
b) tacrolimus (FK506)
c) mycophenolate
d) mofetil
e) azathioprine
f) corticosteroids
Pathology: Pathogens
1) group 1 (above)
a) Listeria monocytogenes
b) Mycobacterium species
c) Candida species
d) Aspergillus species
e) Cryptococcus neoformans
f) Herpes simplex virus
g) varicella-zoster virus
2) acquired immunodeficiency syndrome (AIDS)
a) Pneumocystis carinii
b) cytomegalovirus
c) Herpes simplex
d) Mycobacterium avium intracellulare (MAI)
e) Cryptococcus neoformans
f) Candida species
g) also see acquired immunodeficiency syndrome (AIDS)
3) purine nucleoside phosphorylase deficiency
a) fungi
b) viruses
Special laboratory:
- skin test response to PPD, mumps, Candida antigens is deficient
Related
cellular immunity
immunosuppressive agent
mixed cellular & humoral immune dysfunction
Specific
Acquired Immuno-Deficiency Syndrome (HIV infection stage 3, AIDS)
CD4 T lymphocyte deficiency disorder (HIV-negative AIDS)
Chediak-Higashi syndrome
chronic granulomatous disease
chronic mucocutaneous candidiasis
GATA2 deficiency
neutrophil immunodeficiency syndrome
primary T-cell immunodeficiency
General
immunodeficiency; immunodeficiency syndrome
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, 14
American College of Physicians, Philadelphia 1998, 2006
- Harrison's Principles of Internal Medicine, 13th ed.
Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 497