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cell-free DNA in plasma for colorectal cancer screening; Shield DNA test

Indications: - screening for colorectal cancer - cell-free DNA detects 88% of stage 1,2, & 3 colorectal cancers [1] - only detects 13% of precancerous lesions - false positives 10% - Guardant's Shield test (FDA-approved) detects 83% of colorectal cancers [1]

General

cell-free (circulating tumor) DNA in plasma (liquid biopsy, cFDNA, ctDNA)

References

  1. Chung DC, Gray DM II, Singh H et al. A cell-free DNA blood-based test for colorectal cancer screening. N Engl J Med 2024 Mar 14; 390:973 PMID: 38477985 https://www.nejm.org/doi/10.1056/NEJMoa2304714 - Reuters Health Information, July 29, 2024 US FDA Approves Guardant Health's Blood-based Cancer Test. https://www.medscape.com/s/viewarticle/us-fda-approves-guardant-healths-blood-based-cancer-test-2024a1000duo
  2. Zhao F, Bai P, Xu J, Li Z, Muhammad S, Li D, Zhang Z, Gao Y, Liu Q. Efficacy of cell-free DNA methylation-based blood test for colorectal cancer screening in high-risk population: a prospective cohort study. Mol Cancer. 2023 Sep 28;22(1):157. PMID: 37770864 PMCID: PMC10538018 Free PMC article.