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cefmetazole (Zefazone)
Tradename: Zefazone. 2nd generation cephalosporin.
Dosage: 2 g IV every 6-12 hours.
Antimicrobial activity:
Gram positive
- Streptococcus
- Streptococcus group A
- Streptococcus group B
- Streptococcus group C
- Streptococcus group G
- Streptococcus pneumonia
- Streptococcus viridans, milleri
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis (+/-)
Gram negative
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Moraxella catarrhalis
- Haemophilus influenzae
- Escherichia coli
- Klebsiella species
- Salmonella species
- Shigella species
- Proteus mirabilis
- Proteus vulgaris
- Providencia species
- Morganella species
- Citrobacter species (+/-)
- Aeromonas species (+/-)
Anaerobes
- Bacteroides fragilis
- Bacteroides melaninogenicus
- Clostridium species
- Peptostreptococcus species
Adverse effects:
- bleeding secondary to coagulopathy (in elderly)
Drug interactions:
1) coadministration with alcohol may produce a disulfiram-like reaction
2) cefmetazole may enhance the effect of warfarin
Interactions
drug interactions
drug adverse effects of cephalosporins
General
cephalosporin, 2nd generation
Properties
MISC-INFO: elimination route KIDNEY
pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Sanford Guide to antimicrobial therapy 1997
- Deprecated Reference