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cefixime (Suprax)
Tradename: Suprax. 3rd generation cephalosporin. Suprax discontinued 2003; back on the market summer in 2004 [4,5]
Indications:
1) treatment of uncomplicated urinary tract infections
2) otitis media
3) upper respiratory tract infections
a) pharyngitis
b) tonsillitis
4) bronchitis [8]
5) single dose treatment of gonorrhea
Contraindications:
1) hypersensitivity to cefixime or cephalosporins
2) use with caution in patients allergic to penicillin
Dosage:
1) 400 mg PO QD or 200 mg PO BID
2) Children: 8 mg/kg/day divided QD/BID
3) gonorrhea: 400 mg PO single dose
Tabs: 200, 400 mg, Suspension: 100 mg/5 mL.
Dosage adjustment in renal failure:
Antimicrobial activity:
Gram positive
- Streptococcus
- Streptococcus group A
- Streptococcus group B
- Streptococcus group C
- Streptococcus group G
- Streptococcus pneumonia
- Streptococcus viridans, milleri
Gram negative
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Moraxella catarrhalis
- Haemophilus
- Haemophilus influenzae
- Haemophilus parainfluenzae
- Haemophilus parahaemolyticus [8]
- Escherichia coli
- Klebsiella species
- Serratia species (+/-)
- Salmonella species
- Shigella species
- Proteus mirabilis
- Proteus vulgaris
- Providencia species
- Citrobacter species
- Aeromonas species
- Yersinia enterocolitica
- Pasteurella multocida
- Haemophilus ducreyi
Anaerobes
- Bacteroides melaninogenicus
- Peptostreptococcus species
Adverse effects:
1) not common (1-10%)
- diarrhea, abdominal pain, nausea, dyspepsia, flatulence
2) uncommon (< 1%)
- rash, urticaria, pruritus, headache, dizziness, thrombocytopenia, leukopenia, eosinophilia, vaginitis
3) other
- prolonged use may result in superinfection
Drug interactions:
1) probenecid increases serum levels
2) may interfere with oral contraceptives
Interactions
drug interactions
drug adverse effects of cephalosporins
General
cephalosporin, 3rd generation
Properties
MISC-INFO: elimination route LIVER
KIDNEY
pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM cid=54362
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Sanford Guide to antimicrobial therapy 1997
- Prescriber's Letter 10(1):3 2003
- Cefixime (Suprax) Returns to the Market in the United States
Prescriber's Letter 11(4):21 2004
Detail-Document#: 200409
(subscription needed) http://www.prescribersletter.com
- Department of Veterans Affairs, VA National Formulary
- Prescriber's Letter 15(6): 2008
Expedited Partner Therapy (EPT) for Chlamydia and Gonorrhea
Detail-Document#: 240601
(subscription needed) http://www.prescribersletter.com
- Deprecated Reference