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cefaclor (Ceclor)
Tradename: Ceclor. 2nd generation cephalosporin.
Indications:
1) bacterial infection due to susceptible organisms
2) respiratory tract infections
a) upper respiratory tract infection
1] pharyngitis
2] tonsillitis [4]
3] sinusitis
b) lower respiratory tract infection
- pneumonia [4]
3) otitis media
4) skin infections & infection of skin appendages
5) urinary tract infection
6) empiric treatment of fever of unknown origin [4]
Dosage:
1) 250-500 mg PO TID
2) Pediatrics: 20-40 mg/kg/day divided TID.
Tabs: 250, 500 mg
Elixir: 125, 187, 250 & 375 mg/5 mL.
Dosage adjustment in renal failure:
- administer 50% of dose if creatinine clearance < 50 mL/min
Pharmacokinetics:
- moderately dializable: 20-50%
Antimicrobial activity:
Gram positive
- Streptococcus
- Streptococcus group A
- Streptococcus group B
- Streptococcus group C
- Streptococcus group G
- Streptococcus pneumonia
- Streptococcus viridans, milleri
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis (+/-)
Gram negative
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Moraxella catarrhalis
- Haemophilus influenzae
- Escherichia coli
- Klebsiella species
- Citrobacter species (+/-)
Anaerobes
- Bacteroides melaninogenicus
- Peptostreptococcus species
Adverse effects:
1) not common (1-10%)
- pseudomembranous colitis, diarrhea
2) uncommon (< 1%)
- rash, urticaria, pruritus, nausea, eosinophilia, cholestatic jaundice, arthralgia, Stevens-Johnson syndrome, vomiting, increased serum transaminases (mild), hemolytic anemia, neutropenia
3) other: serum sickness-like reaction [3]
Interactions
drug interactions
drug adverse effects of cephalosporins
General
cephalosporin, 2nd generation
Properties
MISC-INFO: elimination route KIDNEY
pregnancy-category B
safety in lactation ?
elimination by hemodialysis +/-
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Sanford Guide to antimicrobial therapy 1997
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Deprecated Reference
- Department of Veterans Affairs, VA National Formulary