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CCAAT/enhancer-binding protein-delta; C/EBP delta; nuclear factor NF-IL6-beta; NF-IL6-beta (CEBPD)
Function:
- C/EBP is a DNA-binding protein that recognizes two different motifs:
a) CCAAT homology common to many promoters
b) enhanced core homology common to many enhancers
- transcriptional activator in the regulation of genes involved in immune & inflammatory responses
- role in regulation of activation &/or differentiation of macrophages
- binds DNA as a dimer & can form stable heterodimers with C/EBP alpha
- interacts with SPI1/PU.1 (putative)
Structure:
- belongs to the bZIP family, C/EBP subfamily
- contains 1 bZIP domain
Compartment: nucleus
General
CCAAT/enhancer binding protein (C/EBP, CBF, NF-Y protein)
Properties
CONFIGURATION: dimer
SIZE: entity length = 269 aa
MW = 28 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 197-215
leucine zipper
SITE: 226-254
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 116898
UniProt P49716
Pfam PF07716
Kegg hsa:1052
References
- OMIM :accession 116898
- UniProt :accession P49716