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CCAAT/enhancer-binding protein-beta; C/EBP beta; nuclear factor NF-IL6; transcription factor 5 (CEBPB, TCF5, PP9092)

Function: - transcriptional activator - role in regulation of immune & inflammatory responses - specifically binds to an IL-1 response element in the IL-6 gene - role in hippocampal memory consolidation via upregulatation of IGF2 - NF-IL6 also binds to regulatory regions of several acute-phase & cytokines genes - role in regulation of acute-phase reaction, inflammation & hemopoiesis - consensus recognition site is 5'-T[TG]NNGNAA[TG]-3' binds DNA as a dimer & can form stable heterodimers with C/EBP alpha, C/EBP delta & C/EBP gamma - interacts with TRIM28 & PTGES2 (putative) - sumoylated by polymeric chains of SUMO2 or SUMO3 Structure: - belongs to the bZIP family, C/EBP subfamily - contains 1 bZIP domain Compartment: nucleus Expression: expressed at low levels in the lung, kidney & spleen

Related

interleukin-6 dependent DNA binding protein

General

CCAAT/enhancer binding protein (C/EBP, CBF, NF-Y protein)

Properties

CONFIGURATION: dimer SIZE: entity length = 345 aa MW = 36 kD COMPARTMENT: cell nucleus MOTIF: Lys-174 sumoylation {1-24} proline-rich region SITE: 162-170 MOTIF: proline residue (SEVERAL) DNA-binding motif SITE: 277-293 leucine zipper SITE: 306-334 FOR-BINDING-VIA: leucine zipper

Database Correlations

OMIM 189965 UniProt P17676 Pfam PF07716 Kegg hsa:1051

References

  1. UniProt :accession P17676
  2. SeattleSNPs http://pga.gs.washington.edu/data/cebpb/