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CCAAT/enhancer-binding protein-alpha; C/EBP alpha (CEBPA)
Function:
- C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters & the enhanced core homology common to many enhancers
- binds DNA as a dimer & can form stable heterodimers with C/EBP beta & C/EBP gamma
- interacts with UBN1
- interacts with HBV protein X
Structure:
- belongs to the bZIP family, C/EBP subfamily
- contains 1 bZIP domain
Compartment: nucleus
Related
CEBPA gene mutation
General
CCAAT/enhancer binding protein (C/EBP, CBF, NF-Y protein)
Properties
CONFIGURATION: dimer
SIZE: entity length = 358 aa
MW = 38 kD
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {99-104}
proline-rich region
SITE: 183-189
MOTIF: proline residue (SEVERAL)
DNA-binding motif
SITE: 286-306
leucine zipper
SITE: 317-345
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 116897
MORBIDMAP 116897
UniProt P49715
Pfam PF07716
Kegg hsa:1050
References
- OMIM :accession 116897
- UniProt :accession P49715
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/CEBPAID40050ch19q13.html
SeattleSNPs
http://pga.gs.washington.edu/data/cebpa/