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carcinoembryonic antigen-related cell adhesion molecule 1; biliary glycoprotein 1; BGP-1; CD66a (CEACAM1, BGP, BGP1)

Function: - can activate neutrophils - may regulate CD11/CD18 activity Structure: - belongs to the immunoglobulin superfamily, CEA family - contains 3 Ig-like C2-type domain (immunoglobulin-like) - contains 1 Ig-like V-type domain (immunoglobulin-like) Compartment: - isoform A: cell membrane; type 1 membrane protein - isoform B: cell membrane; type 1 membrane protein - isoform C: cell membrane; type 1 membrane protein - isoform G: secreted - isoform H: secreted - isoform I: secreted Alternative splicing: named isoforms=7; A,B,C,D,G,H,I Expression: - granulocytes - epithelial cells Pathology: - receptor for Neisseria gonorrhea & N meningitidis - loss or reduced expression in colorectal carcinoma - increased serum levels of BGP-1 are found in individuals with from hepatic disorders

General

carcinoembryonic antigen (CEA) family protein or carcinoembryonic antigen-related cell adhesion molecule (CEACAM) cluster-of-differentiation antigen; cluster designation antigen; CD antigen

Properties

SIZE: entity length = 526 aa MW = 58 kD COMPARTMENT: plasma membrane MOTIF: signal sequence {1-34} immunoglobulin superfamily domain {35-142} MOTIF: N-glycosylation site {N104} N-glycosylation site {N111} N-glycosylation site {N115} immunoglobulin superfamily domain {145-232} MOTIF: N-glycosylation site {N152} cysteine residue {C167} MODIFICATION: cysteine residue {C215} N-glycosylation site {N182} N-glycosylation site {N197} N-glycosylation site {N208} cysteine residue {C215} MODIFICATION: cysteine residue {C167} N-glycosylation site {N224} N-glycosylation site {N232} immunoglobulin superfamily domain {237-317} MOTIF: N-glycosylation site {N254} cysteine residue {C259} MODIFICATION: cysteine residue {C299} N-glycosylation site {N274} N-glycosylation site {N288} N-glycosylation site {N292} cysteine residue {C299} MODIFICATION: cysteine residue {C259} N-glycosylation site {N302} N-glycosylation site {N309} immunoglobulin superfamily domain {323-413} MOTIF: N-glycosylation site {N345} cysteine residue {C348} MODIFICATION: cysteine residue {C396} N-glycosylation site {N351} N-glycosylation site {N363} N-glycosylation site {N378} cysteine residue {C396} MODIFICATION: cysteine residue {C348} N-glycosylation site {N405} transmembrane domain {429-452}

Database Correlations

OMIM 109770 UniProt P13688 PFAM correlations Entrez Gene 634

References

  1. UniProt :accession P13688
  2. http://www.pathologyoutlines.com/cdmarkers.html 20 January 2003
  3. Entrez Gene :accession 634