cyclin-dependent kinase-9 (CDK9, serine/threonine protein kinase PITALRE, CDC2L4)

Function: - member of the cyclin-dependent kinase pair P-TEFb (CDK9/cyclin-T complex) - associates with CCNT1/cyclin-T1 to form P-TEFb. - associates with CCNK/cyclin-K - CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II & can substitute for P-TEFb in vitro - component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, & NCL/nucleolin - component of the 7SK snRNP complex Structure: - belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily - contains 1 protein kinase domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: ubiquitous

Properties

SIZE: entity length = 372 aa MW = 43 kD COMPARTMENT: cell nucleus STATE: active state MOTIF: kinase domain SITE: 19-315 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 25-33 ATP-binding site NAME: ATP-binding site SITE: 48-48 aspartate residue {D149} Thr phosphorylation site {T186}

Database Correlations

OMIM 603251 UniProt P50750 Pfam PF00069 Entrez Gene 1025 Kegg hsa:1025 ENZYME correlations

References

UniProt :accession P50750