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cyclin-dependent kinase-3 (CDK3)
Function:
- probably involved in the control of the cell cycle
- interacts with a yet unknown type of cyclin
- can phosphorylate histone H1
- interacts with CABLES1 (putative)
Structure:
- belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family
- CDC2/CDKX subfamily contains 1 protein kinase domain
General
cyclin-dependent kinase (CDK)
Properties
SIZE: entity length = 305 aa
MW = 35 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 4-286
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 10-18
Thr phosphorylation site {T14}
Tyr phosphorylation site {Y15}
Tyr phosphorylation site {Y19}
ATP-binding site
NAME: ATP-binding site
SITE: 33-33
aspartate residue {D127}
Thr-phosphate {T160}
Ser phosphorylation site {S207}
Database Correlations
OMIM 123828
UniProt Q00526
Pfam PF00069
Entrez Gene 1018
Kegg hsa:1018
ENZYME 2.7.11.22
References
- Dulie V, Lees E, Reed SI.
Association of human cyclin E with a periodic G1-S phase
protein kinase.
Science. 1992 Sep 25;257(5078):1958-61.
PMID: 1329201
- Solomon MJ.
The function(s) of CAK, the p34cdc2-activating kinase.
Trends Biochem Sci. 1994 Nov;19(11):496-500.
PMID: 7855894
- UniProt :accession Q00526