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CDK1/cyclin B complex or maturation promoting factor (MPF)

M phase H1 kinase activity. MPF (CDK1/cyclin B) controls entry into mitosis.

Interactions

molecular events

General

CDK/cyclin complex growth factor serine/threonine kinase

Figures/Diagrams

Figures/diagrams/slides/tables related to maturation promoting factor (MPF)

Properties

COMPARTMENT: cell nucleus CELL-CYCLE: M STATE: active state SUBUNITS: cyclin-dependent kinase-1 MOTIF: kinase domain SITE: 4-287 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 10-18 Thr phosphorylation site {T14} Tyr phosphorylation site {Y15} Tyr phosphorylation site {Y19} ATP-binding site NAME: ATP-binding site SITE: 33-33 aspartate residue {D128} Thr phosphorylation site {T161} Thr-phosphate {T161} binding site EFFECTOR-BOUND: cyclin B BOUND-VIA: cyclin box cyclin B MOTIF: ubiquitination site (destruction box, D-box) SITE: N-TERMINAL FOR-BINDING-OF: ubiquitin PEST region MODIFICATION: phosphate cyclin box EFFECTOR-BOUND: cyclin-dependent kinase-1 BOUND-VIA: binding site

References

  1. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. No abstract available. PMID: 1988147
  2. Meijer et al EMBO J 10:1545 1991

Component-of

molecular complex

Components

cyclin B cyclin-dependent kinase-1 (CDK1), cell division control protein-2 (cdc2), p34 protein kinase or p34cdc2