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cadherin-2; neural cadherin; N-cadherin; CDw325; CD325 (CDH2, CDHN, NCAD)
Function:
- cadherin
- may be involved in neuronal recognition
- interacts with CDCP1
Structure: contains 5 cadherin domains
Compartment: cell membrane
Genetics:
- there may be two cadherin genes: one at 5p13-14 (N-cadherin 2) & the other on chromosome 18
General
cadherin
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 906 aa
MW = 100 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-25}
cadherin domain {160-267}
MOTIF: N-glycosylation site {N190}
cadherin domain {268-382}
MOTIF: N-glycosylation site {N273}
N-glycosylation site {N325}
cadherin domain {383-497}
MOTIF: N-glycosylation site {N402}
cadherin domain {498-603}
MOTIF: N-glycosylation site {N572}
cadherin domain {604-714}
MOTIF: N-glycosylation site {N651}
N-glycosylation site {N692}
transmembrane domain {725-745}
Tyr phosphorylation site {Y785}
serine-rich region {863-878}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 114020
UniProt P19022
PFAM correlations
Entrez Gene 1000
Kegg hsa:1000
References
- UniProt :accession P19022
- Takeichi M.
Cadherin cell adhesion receptors as a morphogenetic regulator.
Science. 1991 Mar 22;251(5000):1451-5. Review.
PMID: 2006419
- Walsh FS et al
N-cadherin gene maps to human chromosome 18 and is not linked
to the E-cadherin gene.
J Neurochem. 1990 Sep;55(3):805-12.
PMID: 2384753
- Entrez Gene :accession 1000