Search
cadherin-12; brain cadherin; BR-cadherin; neural type cadherin 2; N-cadherin 2 (CDH12)
Function: cadherin (see cadherin)
Structure: contains 5 cadherin domains
Compartment: cell membrane
Expression: brain
Genetics:
- there may be two cadherin genes:
- one at 5p13-14 (N-cadherin 2) & the other on chromosome 18
General
cadherin
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 794 aa
MW = 88 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
cadherin domain {55-160}
cadherin domain {161-269}
MOTIF: N-glycosylation site {N256}
cadherin domain {270-384}
MOTIF: Ser phosphorylation site {S286}
cadherin domain {385-487}
MOTIF: N-glycosylation site {N456}
cadherin domain {488-609}
MOTIF: N-glycosylation site {N537}
N-glycosylation site {N545}
transmembrane domain {610-637}
Database Correlations
OMIM 600562
UniProt P55289
PFAM correlations
Entrez Gene 1010
Kegg hsa:1010
References
- UniProt :accession P55289
- Takeichi M.
Cadherin cell adhesion receptors as a morphogenetic regulator.
Science. 1991 Mar 22;251(5000):1451-5. Review.
PMID: 2006419
- Walsh FS et al
N-cadherin gene maps to human chromosome 18 and is not linked
to the E-cadherin gene.
J Neurochem. 1990 Sep;55(3):805-12.
PMID: 2384753
- Entrez Gene :accession 1010