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cell division cycle 5-like protein; Cdc5-like protein; Pombe cdc5-related protein (CDC5L, KIAA0432, PCDC5RP)
Function:
- DNA-binding protein involved in cell cycle control
- may act as a transcription activator
- also seems to be involved in the second catalytic step of pre-mRNA splicing
- phosphorylated; which enhances interaction with PPP1R8
- interacts with DAPK3 (putative)
- binds to DNA
- binds to adeno-pre-mRNA in an ATP-stimulated manner
- belongs to the spliceosome complex
- part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 & CCAP6
- interacts with PLRG1, Lodestar/TTF2, & NIPP1/PPP1R8
- identified in the spliceosome C complex
Structure:
- homodimer
- belongs to the CEF1 family
- contains 2 HTH myb-type DNA-binding domains
Compartment:
- nuclear speckle, cytoplasm
- may shuttle between cytoplasm & nucleus
Expression:
- ubiquitously expressed in both fetal & adult tissues
Pathology:
- chromosomal translocation t(6;19)(p21;q13.1) involving CDC5L with USF2 is found in multicystic renal dysplasia
General
DNA-binding protein
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 802 aa
MW = 92 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: HTH myb-type 1 {1-56}
MOTIF: DNA-binding motif
SITE: 31-54
HTH myb-type 2 {57-108}
MOTIF: DNA-binding motif
SITE: 82-104
coiled coil {142-245}
MOTIF: Thr phosphorylation site {T227}
PPP1R8 interaction {260-606}
MOTIF: Ser phosphorylation site {S303}
Ser phosphorylation site {S317}
Thr phosphorylation site {T377}
Thr phosphorylation site {T385}
Thr phosphorylation site {T396}
breakpoint {414}
Thr phosphorylation site {T415}
Thr phosphorylation site {T424}
Thr phosphorylation site {T429}
Thr phosphorylation site {T430}
Ser phosphorylation site {S437}
Thr phosphorylation site {T438}
Thr phosphorylation site {T442}
DAPK3 interaction {501-659}
coiled coil {676-701}
PLRG1 interaction {706-800}
coiled coil {764-802}
Database Correlations
OMIM 602868
UniProt Q99459
Pfam PF11831
Entrez Gene 988
Kegg hsa:988
References
- UniProt :accession Q99459
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdc5l/
Component-of
PSO4 complex