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CDC42 homolog; cell division control protein 42 homolog; G25K GTP-binding protein (CDC42)
Function:
- plasma membrane-associated small GTPase & guanine-nucleotide regulatory protein.
- bound by proteins containing CRIB domain
- role in epithelial cell polarization processes
- induces formation of filopodia
- interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B & PARD6G (GTP-dependent)
- interacts with activated CSPG4 & with BAIAP2
- interacts with Zizimin1/DOCK9 & Zizimin2/DOCK11, which activate it by exchanging GDP for GTP.
- interacts with NET1 & TCGAP/SNX26
- part of a complex with PARD3, PARD6A or PARD6B & PRKCI or PRKCZ
Structure:
- belongs to the small GTPase superfamily, Rho family CDC42 subfamily
Compartment:
- cell membrane; lipid-anchor; cytoplasmic side (putative)
Alternative splicing: named isoforms=2
Related
activated CDC42 kinase 1; ACK-1; tyrosine kinase non-receptor protein 2 (TNK2, ACK1)
CDC42 homolog; cell division control protein 42 homolog; G25K GTP-binding protein (CDC42)
CRIB domain (Cdc42/Rac interactive binding domain)
General
rho subfamily protein
Properties
SIZE: entity length = 191 aa
MW = 21 kD
COMPARTMENT: cytoplasm
MOTIF: GTP-binding site
SITE: 10-17
Effector region {32-40}
GTP-binding site
SITE: 57-61
GTP-binding site
SITE: 115-118
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: geranylgeranyl{C20}
BOUND-VIA: cysteine residue
Database Correlations
OMIM 116952
UniProt P60953
Pfam PF00071
Entrez Gene 998
Kegg hsa:998
References
- UniProt :accession P60953
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/CDC42ID40012ch1p36.html
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdc42/
- Entrez Gene :accession 998