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CD84 leukocyte antigen; SLAM family member 5 precursor; signaling lymphocytic activation molecule 5; cell surface antigen MAX.3; Hly9-beta (SLAMF5)
Function:
- homophilic clustering adhesion molecule
- enhances interferon gamma secretion in lymphocytes
- recruits SH2 domain-containing proteins SH2D1A/SAP
- increases proliferative responses of activated T-cells
- SH2D1A/SAP does not seen be required
- induces platelet stimulation (SH2D1A/SAP-dependent)
- marker for hematopoietic progenitor cells
- interacts with SH2 domain-containing proteins SH2D1A/SAP & SH2D1B/hEAT-2
- interaction with tyrosine-protein phosphatases PTPN6 & PTPN11 via its phosphorylated cytoplasmic domain, blocked by SH2D1A
- ITSM motif may bind SH2D1A
- phosphorylated by tyrosine-protein kinase LCK on Tyr following ligation induced by agonist monoclonal antibody
- association with SH2D1A/SAP is dependent on Tyr phosphorylation of its cytoplasmic domain
- phosphorylated on Tyr-296 & Tyr-316 following platelet aggregation
Structure:
- homooligomer, via its extracellular domain
- N-glycosylated
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
Compartment: - cell membrane
Alternative splicing: named isoforms=7
Expression:
- predominantly expressed in hematopoietic tissues, including lymph nodes, spleen, peripheral leukocytes.
- expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells, dentritic cells
- highly expressed in memory T-cells
- expression is slightly increased in naive B-cells after 1st division
- in contrast, expression on memory B-cells decreased with each successive division
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
immunoglobulin superfamily protein
phosphoprotein
Properties
COMPARTMENT: plasma membrane
MOTIF: glycosylation site
membrane region
phosphorylation site
Database Correlations
OMIM 604513
UniProt Q9UIB8
Entrez Gene 8832
References
- Entrez Gene :accession 8832
- http://www.pathologyoutlines.com/cdmarkers.html
20 May 2003
- Protein Reviews on the Web
http://mpr.nci.nih.gov/prow/guide/1984111008_g.htm
- UniProt :accession Q9UIB8