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CD81 antigen; 26 kD cell surface protein TAPA-1; target of the antiproliferative antibody 1; tetraspanin-28; Tspan-28 (CD81, TAPA1, TSPAN28)
Function:
- component of CD19/CD21/Leu-13 signal transduction complex
- role in regulation of cell growth
- interacts directly with IGSF8
Structure:
- not glycosylated (probable)
- belongs to the tetraspanin (TM4SF) family
Compartment: membrane
Expression:
- lymphocytes
- endothelial cells
- epithelial cells
- negative antibody staining in:
- erythrocytes
- platelets
- neutrophils
Pathology:
- may act as a viral receptor for hepatitis C virus (HCV); role in HCV attachment &/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer
- role in the regulation of lymphoma cell growth
- expressed in hematolymphoid, neuroectodermal & mesenchymal tumor cell lines
Related
CD81 or TAPA1 gene
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
tetraspanin (transmembrane-4-superprotein)
Properties
SIZE: entity length = 236 aa
MW = 26 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-12}
transmembrane domain {13-33}
exoplasmic loop {34-63}
transmembrane domain {64-84}
cytoplasmic loop {85-89}
transmembrane domain {90-112}
exoplasmic loop {113-201}
MOTIF: cysteine residue {C156}
MODIFICATION: cysteine residue {C190}
cysteine residue {C157}
MODIFICATION: cysteine residue {C175}
cysteine residue {C175}
MODIFICATION: cysteine residue {C157}
cysteine residue {C190}
MODIFICATION: cysteine residue {C156}
transmembrane domain {202-224}
cytoplasmic domain {225-236}
Database Correlations
OMIM 186845
UniProt P60033
Pfam PF00335
Entrez Gene 975
Kegg hsa:975
References
- Entrez Gene :accession 975
- http://www.pathologyoutlines.com/cdmarkers.html
20 May 2003
- Protein Reviews on the Web
http://mpr.nci.nih.gov/prow/guide/1198972117_g.htm
- UniProt :accession P60033