macrosialin; Gp110; CD68 (CD68)

Function: - may affect macrophage phagocytosis, both in intracellular lysosomal metabolism & extracellular cell-cell & cell-pathogen interactions - binds to tissue- & organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites - rapid recirculation of CD68 from endosomes, lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells Structure: - N- & O-glycosylated - belongs to the LAMP family Compartment: - isoform short: cell membrane - isoform long: endosome membrane - lysosome membrane, lysosomal Alternative splicing: named isoforms=2; long, short Expression: - macrophages/monocytes - basophils - dendritic cells - mast cells - myeloid cells - CD34+ progenitor cells - neutrophils - osteoclasts - activated platelets - B cells - T cells Pathology: - positive staining with antibody in: - AML ~50% - most AML-M4, AML-M5 - some B cell lymphomas - hairy cell leukemia - interdigitating dendritic cell sarcoma - Langerhans cell histiocytosis - mastocytosis - mast cell disease - granular cell tumors - occasional melanoma - rare granular cell type of angiosarcoma

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen lysosome-associated membrane glycoprotein (LAMP) plasma membrane protein sialoglycoprotein

Properties

SIZE: entity length = 354 aa MW = 37 kD COMPARTMENT: lysosome cellular membrane MOTIF: signal sequence {1-21} Mucin-like {23-140} MOTIF: consensus repeat {70-99} N-glycosylation site {N88} N-glycosylation site {N96} consensus repeat {100-129} N-glycosylation site {N118} N-glycosylation site {N126} proline-rich region SITE: 140-152 MOTIF: proline residue (SEVERAL) N-glycosylation site {N164} cysteine residue {C169} MODIFICATION: cysteine residue {C207} N-glycosylation site {N199} cysteine residue {C207} MODIFICATION: cysteine residue {C169} N-glycosylation site {N246} N-glycosylation site {N261} cysteine residue {C277} MODIFICATION: cysteine residue {C314} N-glycosylation site {N279} cysteine residue {C314} MODIFICATION: cysteine residue {C277} transmembrane domain {320-344}

Database Correlations

OMIM 153634 UniProt P34810 Pfam PF01299 Entrez Gene 968 Kegg hsa:968