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CD66e; carcinoembryonic antigen-related cell adhesion molecule 5; carcinoembryonic antigen; CEA; meconium antigen 100; CD66e (CEACAM5, CEA)
Function:
- suggestion CEA may be the fetal counterpart of albumin seems unlikely if CEA is a glypiated protein
- cell surface glycoprotein
- plays a role in cell adhesion & in intracellular signaling
Structure:
- homodimer
- complex immunoreactive glycoprotein with a MW of 180 kD
- contains 60% carbohydrate
- belongs to the immunoglobulin superfamily, CEA family
- contains 7 Ig-like (immunoglobulin-like) domains
Compartment: cell membrane; lipid-anchor, GPI-anchor
Expression:
- neutrophils
- fetal colon
- small intestinal crypts
- apical surfaces of epithelial cells
- small intestinal goblet cell mucin (not intracytoplasmic)
- biliary tract
Pathology:
- expressed in:
a) adenocarcinomas of endodermally derived GI epithelium
b) lung adenocarcinoma
c) colon adenocarcinoma
d) medullary thyroid carcinoma*
- not expressed in:
a) hepatocellular carcinoma
b) mesothelioma
c) renal cell carcinoma
d) prostate adenocarcinoma
e) ovarian carcinoma
f) other thyroid carcinomas* stain negatively with antibody
- receptor for E.coli Dr adhesins; binding of E.coli Dr adhesins leads to dissociation of the homodimer
Diagnostic use: 85% sensitive, 96% specific for lung adenocarcinoma vs. mesothelioma
Notes:
- gene originally CEA, renamed CEACAM5
Related
carcinoembryonic antigen (CEA) in serum/plasma
CD66e Ag in tissue
General
carcinoembryonic antigen (CEA) family protein or carcinoembryonic antigen-related cell adhesion molecule (CEACAM)
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glypiated protein
Properties
SIZE: entity length = 702 aa
MW = 77 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-34}
immunoglobulin superfamily domain {35-144}
MOTIF: N-glycosylation site {N104}
N-glycosylation site {N115}
immunoglobulin superfamily domain {146-237}
MOTIF: N-glycosylation site {N152}
N-glycosylation site {N182}
N-glycosylation site {N197}
N-glycosylation site {N204}
N-glycosylation site {N208}
immunoglobulin superfamily domain {238-322}
MOTIF: N-glycosylation site {N246}
N-glycosylation site {N256}
N-glycosylation site {N274}
N-glycosylation site {N288}
N-glycosylation site {N292}
N-glycosylation site {N309}
immunoglobulin superfamily domain {324-415}
MOTIF: N-glycosylation site {N330}
N-glycosylation site {N351}
N-glycosylation site {N360}
N-glycosylation site {N375}
immunoglobulin superfamily domain {416-498}
MOTIF: N-glycosylation site {N432}
N-glycosylation site {N466}
N-glycosylation site {N480}
immunoglobulin superfamily domain {502-593}
MOTIF: N-glycosylation site {N508}
N-glycosylation site {N529}
N-glycosylation site {N553}
N-glycosylation site {N560}
N-glycosylation site {N580}
immunoglobulin superfamily domain {594-677}
MOTIF: N-glycosylation site {N612}
N-glycosylation site {N650}
N-glycosylation site {N665}
glycosyl phosphatidylinositol [GPI] membrane anchor {N685}
Database Correlations
OMIM 114890
UniProt P06731
PFAM correlations
Entrez Gene 1048
Kegg hsa:1048
References
- http://www.pathologyoutlines.com/cdmarkers.html
20 January 2003
- Entrez Gene :accession 1048