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CD64; high affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI (FCGR1A, FCG1, FCGR1, IGFR1)
Function:
- high affinity receptor binds to Fc region of IgG
- functions in both innate & adaptive immune responses
- phagocytosis & antigen presentation to T cells
- interacts with FCERG1; forms a functional signaling complex
- interacts with FLNA; prevents FCGR1A degradation
- interacts with EPB41L2, LAT & PPL
- phosphorylated on Ser (putative)
Structure:
- N-glycosylated (putative)
- belongs to the immunoglobulin superfamily, FCGR1 family
- contains 3 Ig-like C2-type domain (immunoglobulin-like)
Compartment:
- cell membrane
- stabilized at the cell membrane through interaction with FCER1G
Alternative splicing: named isoforms=2
Expression:
- macrophages/monocytes
- activated granulocytes
- dendritic cells
- early myeloid cells
Pathology:
- expressed in:
- AML AML-M0, AML-M1, AML-M2 (variable), AML-M3 (usually), AML-M4, AML-M5
Related
filamin (actin-binding protein)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
Fc gamma receptor
phosphoprotein
Properties
SIZE: entity length = 374 aa
MW = 43 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-15}
immunoglobulin superfamily domain {22-101}
MOTIF: cysteine residue {C43}
MODIFICATION: cysteine residue {C85}
N-glycosylation site {N59}
N-glycosylation site {N78}
cysteine residue {C85}
MODIFICATION: cysteine residue {C43}
immunoglobulin superfamily domain {95-184}
MOTIF: cysteine residue {C124}
MODIFICATION: cysteine residue {C168}
Tyr phosphorylation site {Y133}
Tyr phosphorylation site {Y138}
N-glycosylation site {N152}
N-glycosylation site {N159}
N-glycosylation site {N163}
cysteine residue {C168}
MODIFICATION: cysteine residue {C124}
immunoglobulin superfamily domain {190-277}
MOTIF: N-glycosylation site {N195}
cysteine residue {C212}
MODIFICATION: cysteine residue {C260}
N-glycosylation site {N240}
cysteine residue {C260}
MODIFICATION: cysteine residue {C212}
transmembrane domain {293-313}
EPB41L2 interaction {312-332}
Database Correlations
OMIM 146760
MORBIDMAP 146760
UniProt P12314
Pfam PF00047
Kegg hsa:2209
References
- Stockinger H et al
Molecular characterization and functional analysis of the
leukocyte surface protein CD31.
J Immunol 145:3889 1990
PMID: 1700999
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- CGR1Abase; Note: FCGR1A mutation db
http://bioinf.uta.fi/FCGR1Abase/
- UniProt :accession P12314