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CD56; neural cell adhesion molecule 1; NCAM-1 (NCAM1, NCAM)

Function: - regulates interactions between neurons & between neurons & muscle - associates with fibroblast growth factor receptor & stimulates tyrosine kinase activity to induce neurite outgrowth Compartment: - secreted - isoforms 1,2: cell membrane, transmembrane domain - isoform 3,4: cell membrane; lipid-anchor, GPI-anchor - isoforms 5,6: secreted Structure: - contains 2 fibronectin F3 modules - contains 5 Ig-like C2-type domains (immunoglobulin-like) Alternative splicing: named isoforms=6 Expression: - NK cells ~80 - 90% - activated T cells - brain, cerebellum - neuromuscular junctions - neuroendocrine tissues Pathology: - expressed in: a) myeloma b) myeloid leukemia c) neuroendocrine tumors d) Wilms tumor e) adult neuroblastoma - primitive neuroectodermal tumors (PNETs) stain negatively with antibody.

Related

CD56 Ag in tissue CD56 cells in specimen

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen immunoglobulin superfamily protein neural cell adhesion molecule phosphoprotein

Properties

SIZE: MW = 84 kD entity length = 761 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-19} immunoglobulin superfamily domain {20-111} MOTIF: cysteine residue {C41} MODIFICATION: cysteine residue {C96} cysteine residue {C96} MODIFICATION: cysteine residue {C41} immunoglobulin superfamily domain {116-205} MOTIF: cysteine residue {C139} MODIFICATION: cysteine residue {C189} cysteine residue {C189} MODIFICATION: cysteine residue {C139} immunoglobulin superfamily domain {212-301} MOTIF: N-glycosylation site {N222} cysteine residue {C235} MODIFICATION: cysteine residue {C287} cysteine residue {C287} MODIFICATION: cysteine residue {C235} immunoglobulin superfamily domain {308-403} MOTIF: N-glycosylation site {N315} cysteine residue {C329} MODIFICATION: cysteine residue {C385} N-glycosylation site {N347} cysteine residue {C385} MODIFICATION: cysteine residue {C329} immunoglobulin superfamily domain {406-491} MOTIF: N-glycosylation site {N423} cysteine residue {C426} MODIFICATION: cysteine residue {C479} N-glycosylation site {N449} N-glycosylation site {N478} cysteine residue {C479} MODIFICATION: cysteine residue {C426} fibronectin type III domain or F3 module {496-595} fibronectin type III domain or F3 module {598-692} transmembrane domain {709-729} Ser phosphorylation site {S774}

Database Correlations

OMIM 116930 UniProt P13591 PFAM correlations Entrez Gene 4684 Kegg hsa:4684

References

  1. Baron M, Norman DG, Campbell ID. Protein modules. Trends Biochem Sci. 1991 Jan;16(1):13-7. Review. PMID: 2053133
  2. Schachner M, Martini R. Glycans and the modulation of neural-recognition molecule function. Trends Neurosci. 1995 Apr;18(4):183-91. Review. PMID: 7539963 (HNK-I)
  3. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
  4. Wikipedia: Neural cell adhesion molecule http://en.wikipedia.org/wiki/Neural_cell_adhesion_molecule
  5. UniProt :accession P13591
  6. Functional glycomics gateway - glycan binding - N-CAM 140 http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Itlect_264