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T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e (CD3E, T3E)
Function:
- component of the CD3 complex
Structure:
- contains 1 Ig-like (immunoglobulin-like) domain
- contains 1 ITAM domain
Compartment: membrane
General
immunoglobulin superfamily protein
oligomerizing protein
phosphoprotein
plasma membrane protein
protein subunit
Properties
SIZE: entity length = 207 aa
MW = 23 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-22}
immunoglobulin superfamily domain {32-112}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C98}
cysteine residue {C98}
MODIFICATION: cysteine residue {C49}
transmembrane domain {127-152}
ITAM {178-205}
MOTIF: Tyr phosphorylation site {Y188}
Tyr phosphorylation site {Y199}
Database Correlations
OMIM 186830
MORBIDMAP 186830
UniProt P07766
Pfam PF02189
Entrez Gene 916
Kegg hsa:916
References
- UniProt :accession P07766
- CD3Ebase; Note: CD3E mutation db
http://bioinf.uta.fi/CD3Ebase/
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CD3E
- Altman A, Coggeshall KM, Mustelin T.
Molecular events mediating T cell activation.
Adv Immunol. 1990;48:227-360. Review. No abstract available.
PMID: 1693465
Component-of
CD3