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T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain; CD3d (CD3D, T3D)
Function:
- component of the CD3 complex
Structure: contains 1 ITAM domain
Compartment: membrane
Pathology:
- defects in CD3D are a cause of severe combined immunodeficiency disease SCIDBNK type
General
glycoprotein
immunoglobulin superfamily protein
phosphoprotein
plasma membrane protein
protein subunit
Properties
SIZE: entity length = 171 aa
MW = 19 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
N-glycosylation site {N38}
N-glycosylation site {N74}
transmembrane domain {106-126}
ITAM {138-166}
MOTIF: Tyr phosphorylation site {Y149}
Tyr phosphorylation site {Y160}
Database Correlations
OMIM correlations
MORBIDMAP 186790
UniProt P04234
Pfam PF02189
Entrez Gene 915
Kegg hsa:915
References
- UniProt :accession P04234
- CD3Dbase; Note: CD3D mutation db
http://bioinf.uta.fi/CD3Dbase/
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CD3D
- Altman A, Coggeshall KM, Mustelin T.
Molecular events mediating T cell activation.
Adv Immunol. 1990;48:227-360. Review. No abstract available.
PMID: 1693465
Component-of
CD3