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CD35, complement component (3b/4b) receptor-1, C3b-1/Epstein Barr Virus [EBV] receptor or C4-binding protein
Function:
- C3b receptor on erythrocytes
- circulates with beta-globulin
- same as C4-binding protein & proline-rich protein of chylomicrons
- mediates cellular binding of particles & immune complexes that have activated complement
Structure:
- monomer
- belongs to the receptors of complement activation (RCA) family
- contains 30 Sushi (CCP/SCR) domains
Compartment: membrane
Expression:
- granulocytes
- macrophages
- B cells
- T cells ~10%
- NK cells
- erythrocytes
- splenic follicular dendritic cells
- eosinophils
- glomerular podocytes
- astrocytes (some)
Polymorphism:
- CR1 contains a system of antigens called the Knops blood group system
- polymorphisms within the Knops blood group system are involved in malarial rosetting, a process associated with cerebral malaria
- common Knops system antigens include McCoy (McC) & Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien)
- Sl(a-) phenotype is more common in persons of African descent & may protect against fatal malaria
Related
CD35 Ag in tissue
complement C3b
General
beta globulin
complement-3b [C3b] receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
proline-rich protein
virus receptor
Properties
SIZE: entity length = 2039 aa
MW = 224 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-41}
Sushi domain {42-1967} (30)
MOTIF: cysteine residue {C43}
MODIFICATION: cysteine residue {C86}
N-glycosylation site {N56}
cysteine residue {C73}
MODIFICATION: cysteine residue {C99}
cysteine residue {C86}
MODIFICATION: cysteine residue {C43}
cysteine residue {C99}
MODIFICATION: cysteine residue {C73}
transmembrane domain {1972-1996}
Database Correlations
OMIM correlations
UniProt P17927
Pfam PF00084
Entrez Gene 1378
Kegg hsa:1378
References
- Tsokos et al J Immunol 1990 Mar 1;144(5):1640-5
- OMIM :accession 120620
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- BGMUT; Note: Blood group antigen gene mutation database
http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=knops
- UniProt :accession P17927