CD302 (C-type lectin domain family 13 member A, C-type lectin BIMLEC, type 1 transmembrane C-type lectin receptor DCL-1, CLEC13A, DCL1, KIAA0022)

Structure: contains 1 C-type lectin domain Compartment: membrane Alternative splicing: named isoforms=3 Expression: - expressed in myeloid & B lymphoid cell lines Pathology: - isoforms 2 & 3 are expressed in malignant Hodgkin's lymphoma Reed-Sternberg cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 & CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen C-type (calcium dependent, carbohydrate-recognition domain) lectin superfamily or C-type lectin domain family membrane protein

Properties

SIZE: MW = 26 kD entity length = 232 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-22} C-type lectin {32-152} MOTIF: cysteine residue {C128} MODIFICATION: cysteine residue {C143} cysteine residue {C143} MODIFICATION: cysteine residue {C128} transmembrane domain {169-189}

Database Correlations

UniProt Q8IX05 Pfam PF00059

References

UniProt :accession Q8IX05