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CD3

Function: - associates with the T-cell receptor as the TcR/CD3 complex - mediates signal transduction Structure: - 90% of CD3 proteins contain gamma or delta & epsilon & zeta homodimers - single cells contain both gamma-epsilon(2) -zeta(2) & delta-epsilon(2)-zeta(2) CD3/TCR complexes - in 10% of CD3, zeta homodimers are replaced by zeta-eta heterodimer Expression: - thymocytes - peripheral T cells - NK cells - Purkinje cells of cerebellum Pathology: - expressed in T cell lymphomas ~80% Laboratory: - most specific T cell marker - CD3 cells in specimen - CD3 cells in tissue - CD3 cells in body fluid - CD3 (cytoplasmic) cells in body fluid - CD3 cells in blood - CD3 (cytoplasmic) cells in blood - CD3 (cytoplasmic) blasts in blood

Interactions

molecular events

Related

CD3 Ag in tissue CD3 omega subunit CD3+CD20 Ag in tissue T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain; CD3d (CD3D, T3D)

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein multisubunit protein phosphoprotein

Figures/Diagrams

TNFR/IL1R1/CD28/TCR-CD3 -> NF kappa B

Properties

COMPARTMENT: plasma membrane CELL: T-cell SUBUNITS: T-cell surface glycoprotein CD3 gamma chain MOTIF: signal sequence {1-22} immunoglobulin superfamily domain {37-94} MOTIF: cysteine residue {C46} MODIFICATION: cysteine residue {C87} N-glycosylation site {N52} cysteine residue {C87} MODIFICATION: cysteine residue {C46} N-glycosylation site {N92} transmembrane domain {117-137} Ser phosphorylation site {S145} Ser phosphorylation site {S148} ITAM {149-177} MOTIF: Di-leucine {153-154} Tyr phosphorylation site {Y160} Tyr phosphorylation site {Y171} T-cell surface glycoprotein CD3 epsilon chain CONFIGURATION: dimer MOTIF: signal sequence {1-22} immunoglobulin superfamily domain {32-112} MOTIF: cysteine residue {C49} MODIFICATION: cysteine residue {C98} cysteine residue {C98} MODIFICATION: cysteine residue {C49} transmembrane domain {127-152} ITAM {178-205} MOTIF: Tyr phosphorylation site {Y188} Tyr phosphorylation site {Y199} T-cell surface glycoprotein CD3 zeta chain CONFIGURATION: dimer MOTIF: signal sequence {1-21} transmembrane domain {31-51} MOTIF: cysteine residue {C32} MODIFICATION: cysteine residue {C-INTERCHAIN} Ser phosphorylation site {S58} ITAM 1 {61-89} MOTIF: Tyr phosphorylation site {Y64} Tyr phosphorylation site {Y72} Tyr phosphorylation site {Y83} ITAM 2 {100-128} MOTIF: Tyr phosphorylation site {Y111} Tyr phosphorylation site {Y123} ITAM 3 {131-159} MOTIF: Tyr phosphorylation site {Y142} Tyr phosphorylation site {Y153}

References

  1. Springer TA. Adhesion receptors of the immune system. Nature. 1990 Aug 2;346(6283):425-34. Review. PMID: 1974032
  2. Altman A, Coggeshall KM, Mustelin T. Molecular events mediating T cell activation. Adv Immunol. 1990;48:227-360. Review. No abstract available. PMID: 1693465
  3. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
  4. UniProt :accession P09693

Component-of

T-cell receptor/CD3 complex

Components

CD247; T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain (CD3Z, T3Z, TCRZ) T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain; CD3d (CD3D, T3D) T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e (CD3E, T3E) T-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain; CD3g (CD3G, T3G)