Toll-like receptor 3; CD283 (TLR3)

Function: 1) innate immune response to microbial agents 2) recognition of dsRNA of viral origin (putative) - binding of ds-RNA is required for the interaction with SRC 3) acts via MyD88 & TRAF6 a) NF-kappa-B activation b) cytokine secretion c) inflammatory response 4) may attenuate allergic response [3] - stimulation decreases allergen-induced BAL eosinophils 5) binds MyD88 via their respective TIR domains 6) interacts with TICAM1 Structure: - homodimer formation is triggered by ligand binding & is required for TLR3 signaling - heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding - belongs to the Toll-like receptor family - contains 22 LRR repeats (leucine-rich repeats) - contains 1 TIR domain Compartment: - endoplasmic reticulum membrane - endosome membrane Expression: - expressed at high level in placenta, pancreas > CD11c+ immature dendritic cells. - only expressed in dendritic cells, NOT in other leukocytes

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein leucine-rich repeat-containing protein (LRRC) phosphoprotein toll-like receptor

Properties

SIZE: entity length = 904 aa MW = 104 kD COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-23} cysteine residue {C28} MODIFICATION: cysteine residue {C37} cysteine residue {C37} MODIFICATION: cysteine residue {C28} leucine-rich repeat SITE: 50-73 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N52} N-glycosylation site {N57} N-glycosylation site {N70} leucine-rich repeat SITE: 75-97 MOTIF: leucine residue (SEVERAL) cysteine residue {C95} MODIFICATION: cysteine residue {C122} leucine-rich repeat SITE: 98-121 MOTIF: leucine residue (SEVERAL) cysteine residue {C122} MODIFICATION: cysteine residue {C95} leucine-rich repeat SITE: 123-145 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N124} leucine-rich repeat SITE: 147-169 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 170-193 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 196-219 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N196} leucine-rich repeat SITE: 247-270 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N247} N-glycosylation site {N252} N-glycosylation site {N265} leucine-rich repeat SITE: 273-296 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N275} N-glycosylation site {N291} leucine-rich repeat SITE: 298-320 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 354-377 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 379-403 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N398} leucine-rich repeat SITE: 406-429 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N413} leucine-rich repeat SITE: 431-454 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 455-478 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 480-504 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 505-528 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N507} leucine-rich repeat SITE: 530-552 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 561-584 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 586-608 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 610-632 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 634-659 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N636} cysteine residue {C649} MODIFICATION: cysteine residue {C677} cysteine residue {C651} MODIFICATION: cysteine residue {C696} N-glycosylation site {N662} cysteine residue {C677} MODIFICATION: cysteine residue {C649} cysteine residue {C696} MODIFICATION: cysteine residue {C651} transmembrane domain {705-725} TIR domain {754-896} MOTIF: Tyr phosphorylation site {Y759} Tyr phosphorylation site {Y858}

Database Correlations

OMIM 603029 MORBIDMAP 603029 UniProt O15455 PFAM correlations Entrez Gene 7098 Kegg hsa:7098