programmed cell death 1 ligand 2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; butyrophilin B7-DC; B7-DC; CD273 (PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2)

Function: - role in costimulatory signaling - essential for T-cell proliferation & IFNG production - interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression & cytokine production - interacts with PDCD1 (putative) Structure: - belongs to the immunoglobulin superfamily, BTN/MOG family - contains 1 Ig-like C2-type domain - contains 1 Ig-like V-type domain Compartment: - isoform 3: secreted (probable) - isoform 2: endomembrane system - isoform 1: cell membrane - single-pass type 1 membrane protein Alternative splicing: named isoforms=3 Expression: - highly expressed in heart, placenta, pancreas, lung & liver - weakly expressed in spleen, lymph nodes & thymus - up-regulated by IFNG/IFN-gamma stimulation in monocytes - induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 & IL4/interleukin-4

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein

Properties

SIZE: MW = 31 kD entity length = 273 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} immunoglobulin superfamily domain {21-118} MOTIF: N-glycosylation site {N37} cysteine residue {C42} MODIFICATION: cysteine residue {C102} N-glycosylation site {N64} cysteine residue {C102} MODIFICATION: cysteine residue {C42} immunoglobulin superfamily domain {122-203} MOTIF: cysteine residue {C143} MODIFICATION: cysteine residue {C192} N-glycosylation site {N157} N-glycosylation site {N163} N-glycosylation site {N189} cysteine residue {C192} MODIFICATION: cysteine residue {C143} transmembrane domain {221-241}

Database Correlations

OMIM 605723 UniProt Q9BQ51 Entrez Gene 80380 Kegg hsa:80380

References

UniProt :accession Q9BQ51