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CD23; low affinity immunoglobulin epsilon Fc receptor; lymphocyte IgE receptor; Fc-epsilon-RII; BLAST-2; immunoglobulin E-binding factor (FCER2, CD23A, FCE2, IGEBF)
Function:
- low affinity IgE Fc receptor
- associates with/activates fyn [2]
- triggers release of monokines by monocytes
- B cell growth factor, promoting differentiation into plasma cells
- regulation of IgE production
Structure:
- N- & O-glycosylated
- contains 1 C-type lectin domain
Compartment:
- cell membrane
- also exists as a soluble excreted form
Alternative splicing: named isoforms=2
Expression:
- activated mature B cells expressing IgM or IgD
- other B cells stain negatively with antibody
- monocytes/macrophages
- subset of T cells
- platelets
- eosinophils
- Langerhans cells
- follicular dendritic cells
Pathology:
- expressed in B-cell CLL/SLL
- mantle cell lymphoma stains negatively with antibody
Laboratory:
- CD21 & CD23 are dendritic cell markers
Interactions
molecular events
Related
CD23 Ag in tissue
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
Fc epsilon receptor
Properties
SIZE: MW = 36 kD
entity length = 321 aa
COMPARTMENT: plasma membrane
CELL: B lymphocyte
MOTIF: transmembrane domain {22-47}
N-glycosylation site {N63}
proteolytic site {149-150}
cysteine residue {C160}
MODIFICATION: cysteine residue {C288}
C-type lectin {162-284}
MOTIF: cysteine residue {C163}
MODIFICATION: cysteine residue {C174}
cysteine residue {C174}
MODIFICATION: cysteine residue {C163}
cysteine residue {C191}
MODIFICATION: cysteine residue {C282}
cysteine residue {C259}
MODIFICATION: cysteine residue {C273}
cysteine residue {C273}
MODIFICATION: cysteine residue {C259}
cysteine residue {C282}
MODIFICATION: cysteine residue {C191}
cysteine residue {C288}
MODIFICATION: cysteine residue {C160}
Database Correlations
OMIM 151445
UniProt P06734
References
- Kolb JP et al
Monoclonal anti-CD23 antibodies induce a rise in [Ca2+]i and
polyphosphoinositide hydrolysis in human activated B cells.
Involvement of a Gp protein.
J Immunol. 1990 Jul 15;145(2):429-37.
PMID: 2164062
- OMIM :accession 151445
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Functional glycomics gateway - glycan binding - Note: CD23
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_221
- UniProt :accession P06734