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CD21; complement receptor type 2; Cr2; complement C3d receptor; Epstein-Barr virus receptor; EBV receptor (CR2, C3DR)
Function:
- receptor for complement C3Dd
- receptor for HNRPU
- participates in B lymphocytes activation
- forms complex with CD19, CD81 & CD225
Structure:
- belongs to the receptors of complement activation (RCA) family
- contains 15 Sushi domains (CCP/SCR)
Compartment: membrane
Alternative splicing: named isoforms=4
Expression:
- mature B-cells; CD21 is present on resting B-cells
- follicular dendritic cells
- T-lymphocytes
- pharyngeal epithelial cells
- astrocytes
Pathology:
- receptor for Epstein-Barr virus on human B-cells & T-cells
- genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9
Laboratory:
- CD21 & CD23 are dendritic cell markers
Related
CD21 Ag in tissue
CD21 cells in body fluid
complement C3d
Epstein-Barr virus (EBV); human herpesvirus 4 (HHV4)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
complement receptor
Properties
SIZE: entity length = 1033 aa
MW = 113 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-20}
Sushi domain {21-659} (10)
MOTIF: cysteine residue {C23}
MODIFICATION: cysteine residue {C65}
cysteine residue {C51}
MODIFICATION: cysteine residue {C82}
cysteine residue {C65}
MODIFICATION: cysteine residue {C23}
cysteine residue {C82}
MODIFICATION: cysteine residue {C51}
Sushi domain {660-716}
MOTIF: cysteine residue {C662}
MODIFICATION: cysteine residue {C699}
N-glycosylation site {N682}
cysteine residue {C685}
MODIFICATION: cysteine residue {C714}
cysteine residue {C699}
MODIFICATION: cysteine residue {C662}
cysteine residue {C714}
MODIFICATION: cysteine residue {C685}
Sushi domain {717-781}
MOTIF: cysteine residue {C719}
MODIFICATION: cysteine residue {C762}
cysteine residue {C748}
MODIFICATION: cysteine residue {C779}
cysteine residue {C762}
MODIFICATION: cysteine residue {C719}
cysteine residue {C779}
MODIFICATION: cysteine residue {C748}
Sushi domain {786-845}
MOTIF: cysteine residue {C788}
MODIFICATION: cysteine residue {C830}
N-glycosylation site {N800}
cysteine residue {C816}
MODIFICATION: cysteine residue {C843}
N-glycosylation site {N823}
cysteine residue {C830}
MODIFICATION: cysteine residue {C788}
cysteine residue {C843}
MODIFICATION: cysteine residue {C816}
Sushi domain {849-909}
MOTIF: cysteine residue {C851}
MODIFICATION: cysteine residue {C894}
N-glycosylation site {N861}
cysteine residue {C880}
MODIFICATION: cysteine residue {C907}
cysteine residue {C894}
MODIFICATION: cysteine residue {C851}
cysteine residue {C907}
MODIFICATION: cysteine residue {C880}
Sushi domain {910-970}
MOTIF: N-glycosylation site {N911}
cysteine residue {C912}
MODIFICATION: cysteine residue {C955}
cysteine residue {C941}
MODIFICATION: cysteine residue {C968}
cysteine residue {C955}
MODIFICATION: cysteine residue {C912}
cysteine residue {C968}
MODIFICATION: cysteine residue {C941}
transmembrane domain {972-999}
Tyr phosphorylation site {Y1029}
Database Correlations
OMIM correlations
MORBIDMAP 120650
UniProt P20023
Pfam PF00084
Kegg hsa:1380
References
- Rijkers et al PNAS 87:8766 1990
- Tsokos et al J Immunol 1990 Mar 1;144(5):1640-5
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- UniProt :accession P20023