CD200 cell surface glycoprotein receptor (cell surface glycoprotein OX2 receptor, CD200 receptor, Mox2 receptor, CD200R1, CD200R, CRTR2, MOX2R, OX2R)

Function: - receptor for CD200 (OX2 cell surface glycoprotein) Structure: - contains 1 Ig-like C2-type domain (immunoglobulin-like) contains 1 Ig-like V-type domain (immunoglobulin-like) Compartment: - isoform 1, 4: cell membrane - isoform 2, 3: secreted Alternative splicing: named isoforms=4 Pathology: - binds to HHV-8 K14 viral OX2 homolog with identical affinity & kinetics as the host OX2 (CD200)

General

cell surface receptor glycoprotein

Properties

SIZE: MW = 37 kD entity length = 325 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-28} N-glycosylation site {N37} N-glycosylation site {N46} immunoglobulin superfamily domain {53-139} MOTIF: cysteine residue {C60} MODIFICATION: cysteine residue {C132} N-glycosylation site {N93} N-glycosylation site {N99} cysteine residue {C132} MODIFICATION: cysteine residue {C60} immunoglobulin superfamily domain {140-228} MOTIF: N-glycosylation site {N162} cysteine residue {C167} MODIFICATION: cysteine residue {C216} N-glycosylation site {N195} N-glycosylation site {N210} cysteine residue {C216} MODIFICATION: cysteine residue {C167} N-glycosylation site {N224} transmembrane domain {244-264}

Database Correlations

OMIM 607546 UniProt Q8TD46 Pfam PF08205

References

UniProt :accession Q8TD46