Search
CD2; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; LFA-2; LFA-3 receptor; erythrocyte receptor; rosette receptor (SRBC)
Function:
- interacts with LFA-3 & CD48/BCM1 to mediate adhesion between T-cells & other cell types
- implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function
- may associate with lck [5]
- interacts with CD2AP (putative)
- interacts with PSTPIP1
Structure:
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Expression:
- thymocytes ~95%
- almost all peripheral T cells
- NK cells 80-90%
- thymic B cells ~50%
Interactions
molecular events
Related
CD2 Ag in tissue
CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein, CD2 tail-binding protein, CD2BP2, KIAA1178)
CD2 cells in specimen
Specific
CD2R
General
adhesion receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: MW = 50 kD
COMPARTMENT: plasma membrane
CELL: T-cell
NK cell
MOTIF: signal sequence {1-24}
immunoglobulin superfamily domain {25-128}
MOTIF: LFA-3 (CD58) binding region 1 {61-75}
N-glycosylation site {N89}
LFA-3 (CD58) binding region 2 {106-120}
immunoglobulin superfamily domain {129-209}
MOTIF: cysteine residue {C139}
MODIFICATION: cysteine residue {C203}
N-glycosylation site {N141}
cysteine residue {C146}
MODIFICATION: cysteine residue {C186}
N-glycosylation site {N150}
cysteine residue {C186}
MODIFICATION: cysteine residue {C146}
cysteine residue {C203}
MODIFICATION: cysteine residue {C139}
transmembrane domain {210-235}
proline-rich region
SITE: 282-338
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 186990
UniProt P06729
PFAM correlations
Entrez Gene 914
Kegg hsa:914
References
- Cotran et al Robbins Pathologic Basis of Disease,
W.B. Saunders Co, Philadelphia, PA 1989 pg 165
- Le Gouvello S, Colard O, Theodorou I, Bismuth G, Tarantino N,
Debre P.
CD2 triggering stimulates a phospholipase A2 activity beside
the phospholipase C pathway in human T lymphocytes.
J Immunol. 1990 Mar 15;144(6):2359-64.
PMID: 1968928
- Springer TA.
Adhesion receptors of the immune system.
Nature. 1990 Aug 2;346(6283):425-34. Review.
PMID: 1974032
- Altman A, Coggeshall KM, Mustelin T.
Molecular events mediating T cell activation.
Adv Immunol. 1990;48:227-360. Review.
PMID: 1693465
- Bolen JB, Rowley RB, Spana C, Tsygankov AY.
The Src family of tyrosine protein kinases in hemopoietic
signal transduction.
FASEB J. 1992 Dec;6(15):3403-9. Review.
PMID: 1281458
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Wikipedia; Note: CD2 entry
http://en.wikipedia.org/wiki/CD2
- Wikipedia; Note: CD2 entry
http://en.wikipedia.org/wiki/CD2
Component-of
molecular complex